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The definitive guide to the myriad analytical techniques available to scientists involved in biotherapeutics research Analytical Characterization of Biotherapeutics covers all current and emerging analytical tools and techniques used for the characterization of therapeutic proteins and antigen reagents. From basic recombinant antigen and antibody characterization, to complex analyses for increasingly complex molecular designs, the book explores the history of the analysis techniques and offers valuable insights into the most important emerging analytical solutions. In addition, it frames critical questions warranting attention in the design and delivery of a therapeutic protein, exposes analytical challenges that may occur when characterizing these molecules, and presents a number of tested solutions. The first single-volume guide of its kind, Analytical Characterization of Biotherapeutics brings together contributions from scientists at the leading edge of biotherapeutics research and manufacturing. Key topics covered in-depth include the structural characterization of recombinant proteins and antibodies, antibody de novo sequencing, characterization of antibody drug conjugates, characterization of bi-specific or other hybrid molecules, characterization of manufacturing host-cell contaminant proteins, analytical tools for biologics molecular assessment, and more. Each chapter is written by a recognized expert or experts in their field who discuss current and cutting edge approaches to fully characterizing biotherapeutic proteins and antigen reagents Covers the full range of characterization strategies for large molecule based therapeutics Provides an up-to-date account of the latest approaches used for large molecule characterization Chapters cover the background needed to understand the challenges at hand, solutions to characterize these large molecules, and a summary of emerging options for analytical characterization Analytical Characterization of Biotherapeutics is an up-to-date resource for analytical scientists, biologists, and mass spectrometrists involved in the analysis of biomolecules, as well as scientists employed in the pharmaceuticals and biotechnology industries. Graduate students in biology and analytical science, and their instructors will find it to be fascinating and instructive supplementary reading.

Presents current research into electromagnetic computation theories with particular emphasis on Finite-Difference Time-Domain Method This book is the first to consolidate current research and to examine the theories of electromagnetic computation methods in relation to lightning surge protection. The authors introduce and compare existing electromagnetic computation methods such as the method of moments (MOM), the partial element equivalent circuit (PEEC), the finite element method (FEM), the transmission-line modeling (TLM) method, and the finite-difference time-domain (FDTD) method. The application of FDTD method to lightning protection studies is a topic that has matured through many practical applications in the past decade, and the authors explain the derivation of Maxwell’s equations required by the FDTD, and modeling of various electrical components needed in computing lightning electromagnetic fields and surges with the FDTD method. The book describes the application of FDTD method to current and emerging problems of lightning surge protection of continuously more complex installations, particularly in critical infrastructures of energy and information, such as overhead power lines, air-insulated sub-stations, wind turbine generator towers and telecommunication towers. Both authors are internationally recognized experts in the area of lightning study and this is the first book to present current research in lightning surge protection Examines in detail why lightning surges occur and what can be done to protect against them Includes theories of electromagnetic computation methods and many examples of their application Accompanied by a sample printed program based on the finite-difference time-domain (FDTD) method written in C++ program

By focusing on the cellular mechanisms that underlie ontogeny, phylogeny and regeneration of complex physiologic traits, Evolution, the Logic of Biology demonstrates the use of homeostasis, the fundamental principle of physiology and medicine, as the unifying mechanism for evolution as all of biology. The homeostasis principle can be used to understand how environmental stressors have affected physiologic mechanisms to generate condition-specific novelty through cellular mechanisms. Evolution, the Logic of Biology allows the reader to understand the vertebrate life-cycle as an intergenerational continuum in support of effective, on-going environmental adaptation. By understanding the principles of physiology from their fundamental unicellular origins, culminating in modern-day metazoans, the reader as student, researcher or practitioner will be encouraged to think in terms of the prevention of disease, rather than in the treatment of disease as the eradication of symptoms. By tracing the ontogeny and phylogeny of this and other phenotypic homologies, one can perceive and understand how complex physiologic traits have mechanistically evolved from their simpler ancestral and developmental origins as cellular structures and functions, providing a logic of biology for the first time. Evolution, the Logic of Biology will be an invaluable resource for graduate students and researchers studying evolutionary development, medicine and biology, anthropology, comparative and developmental biology, genetics and genomics, and physiology.

Provides corrosion basics in a lucid manner to students and working professionals and over 80 corrosion-failure analysis case studies Correlates Failure Analysis with Corrosion Science Exclusively provides corrosion-related failure analysis case histories in one place in a convenient format One-stop shop for both science and real time occurrence of the phenomenon of corrosion Full coverage of all MOC, Materials of Construction, used for process equipments Simple but Lucid presentation of Failure Analysis procedure

The International System of Units (SI) is the world's most widely used system of measurement, used every day in commerce and science, and is the modern form of the metric system. It currently comprises the meter (m), the kilogram (kg), the second (s), the ampere (A), the kelvin (K), the candela (cd) and the mole (mol)). The system is changing though, units and unit definitions are modified through international agreements as the technology of measurement progresses, and as the precision of measurements improves. The SI is now being redefined based on constants of nature and their realization by quantum standards. Therefore, the underlying physics and technologies will receive increasing interest, and not only in the metrology community but in all fields of science. This book introduces and explains the applications of modern physics concepts to metrology, the science and the applications of measurements. A special focus is made on the use of quantum standards for the realization of the forthcoming new SI (the international system of units). The basic physical phenomena are introduced on a level which provides comprehensive information for the experienced reader but also provides a guide for a more intense study of these phenomena for students.

Written with both postgraduate students and researchers in academia and industry in mind, this reference covers the chemistry behind metal nanopowders, including production, characterization, oxidation and combustion. The contributions from renowned international scientists working in the field detail applications in technologies, scale-up processes and safety aspects surrounding their handling and storage.

Authored by two experts working in this important field of research, the timely book covers the latest advances in the synthesis of cyclodextrins, their properties and important industrial applications. To this end, the authors describe covalent and non-covalent assemblies, cyclodextrin inclusion complexes, cyclodextrin polymers, and modified cyclodextrins, resulting in an up-to-date overview of cyclodextrin chemistry. An invaluable reference for organic and polymer chemists in academia as well as those researchers in industry working in polymer, supramolecular and pharmaceutical chemistry, as well as food, textile and cosmetic science.

In the nematic liquid crystal phase, rod-shaped molecules move randomly but remain essentially parallel to one another. Biaxial nematics, which were first predicted in 1970 by Marvin Freiser, have their molecules differentially oriented along two axes. They have the potential to create displays with fast switching times and may have applications in thin-film displays and other liquid crystal technologies. This book is the first to be concerned solely with biaxial nematic liquid crystals, both lyotropic and thermotropic, formed by low molar mass as well as polymeric systems. It opens with a general introduction to the biaxial nematic phase and covers: • Order parameters and distribution functions • Molecular field theory • Theories for hard biaxial particles • Computer simulation of biaxial nematics • Alignment of the phase • Display applications • Characterisation and identification • Lyotropic, thermotropic and colloidal systems together with material design With a consistent, coherent and pedagogical approach, this book brings together theory, simulations and experimental studies; it includes contributions from some of the leading figures in the field. It is relevant to students and researchers as well as to industry professionals working in soft matter, liquid crystals, liquid crystal devices and their applications throughout materials science, chemistry, physics, mathematics and display engineering.

Thermische Trennverfahren verursachen bei der Herstellung von Produkten und Verbrauchsgutern in verfahrenstechnischen Produktionsanlagen haufig den gro?ten Teil der Investitions- und Betriebskosten des Gesamtverfahrens – ihre optimale Gestaltung ist deshalb von gro?er wirtschaftlicher Bedeutung. Anhand von uber 80 Aufgaben und Auslegungsbeispielen hilft das Buch, praxisrelevante Vorgehensweisen im industriellen Umfeld zu verstehen. Die Schritt fur Schritt abgehandelten Beispiele reichen von der Aufgabenstellung am Beginn eines Projektes uber die thermodynamische Auslegung bis hin zur fluiddynamischen Dimensionierung der Apparate. Zur Losung der Aufgaben kommen neben den didaktisch wertvollen 'Papier- und Bleistiftmethoden' auch moderne Prozesssimulations-Werkzeuge und praxisgangige Programme zur Apparatedimensionierung zum Einsatz. Der Leser gewinnt ein Gefuhl dafur, an welchen Stellen uberschlagige Rechnungen sinnvoll sind und bei welchen Problemen eine rigorosere Betrachtung notwendig ist. Die optimale Auslegung eines Verfahrens in einem gesamtwirtschaftlichen Zusammenhang – das Fundament jeder unternehmerischen Entscheidung – kann im Rahmen von Parameterstudien mit Tabellenkalkulationsblattern (EXCEL) online geubt werden, auch wenn dem Leser kein Prozesssimulationswerkzeug zur Verfugung steht. Das Buch nimmt auch Bezug auf die Software WINSORP der RASCHIG GmbH, mit der beispielsweise die fluiddynamische Auslegung von Packungs- und Fullkorperkolonnen fur Absorption- und Rektifikationsprozesse moglich ist. WINSORP ist auf Anfrage kostenfrei bei der Firma RASCHIG GmbH erhaltlich. Die gewahlte vernetzte Darstellung von Arbeitsablaufen zeigt Studierenden und im Berufsleben stehenden Ingenieuren, Chemikern und Physiker in der Verfahrens-, Bioverfahrens- und Lebensmitteltechnik, im Chemieingenieurwesen, Umweltschutz, Anlagen- und Apparatebau den Realfall der industriellen Praxis.

This book discusses the fundamentals of RFID and the state-of-the-art research results in signal processing for RFID, including MIMO, blind source separation, anti-collision, localization, covert RFID and chipless RFID. Aimed at graduate students as well as academic and professional researchers/engineers in RFID technology, it enables readers to become conversant with the latest theory and applications of signal processing for RFID. Key Features: Provides a systematic and comprehensive insight into the application of modern signal processing techniques for RFID systems Discusses the operating principles, channel models of RFID, RFID protocols and analog/digital filter design for RFID Explores RFID-oriented modulation schemes and their performance Highlights research fields such as MIMO for RFID, blind signal processing for RFID, anti-collision of multiple RFID tags, localization with RFID, covert RFID and chipless RFID Contains tables, illustrations and design examples

This book describes various aspects of nanoscience and nanotechnology. It begins with an introduction to nanoscience and nanotechnology and includes a historical prospective, nanotechnology working in nature, man -made nanomaterial and impact of nanotechnology illustrated with examples. It goes on to describes general synthetic approaches and strategies and also deals with the characterization of nanomaterial using modern tools and techniques to give basic understanding to those interested in learning this emerging area. It then deals with different kinds of nanomaterial such as inorganics, carbon based-, nanocomposites and self-assembled/supramolecular nano structures in terms of their varieties, synthesis, properties etc. In addition, it contains chapters devoted to unique properties with mathematical treatment wherever applicable and the novel applications dealing with information technology, pollution control (environment, water), energy, nanomedicine, healthcare, consumer goods etc.

The sounds produced by geophonic, biophonic and technophonic sources are relevant to the function of natural and human modified ecosystems. Passive recording is one of the most non-invasive technologies as its use avoids human intrusion during acoustic surveys and facilitates the accumulation of huge amounts of acoustical data. For the first time, this book collates and reviews the science behind ecoaucostics; illustrating the principles, methods and applications of this exciting new field. Topics covered in this comprehensive volume include; the assessment of biodiversity based on sounds emanating from a variety of environments the best technologies and methods necessary to investigate environmental sounds implications for climate change and urban systems the relationship between landscape ecology and ecoacoustics the conservation of soundscapes and the social value of ecoacoustics areas of potential future research. An invaluable resource for scholars, researchers and students, Ecoacoustics: The Ecological Role of Sounds provides an unrivalled set of ideas, tools and references based on the current state of the field.