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Despite of many years of studies, predicting fluid flow, heat, and chemical transport in fractured-porous media remains a challenge for scientists and engineers worldwide. This monograph is the third in a series on the dynamics of fluids and transport in fractured rock published by the American Geophysical Union (Geophysical Monograph Series, Vol. 162, 2005; and Geophysical Monograph, No. 122, 2000). This monograph is dedicated to the late Dr. Paul Witherspoon for his seminal influence on the development of ideas and methodologies and the birth of contemporary fractured rock hydrogeology, including such fundamental and applied problems as environmental remediation; exploitation of oil, gas, and geothermal resources; disposal of spent nuclear fuel; and geotechnical engineering. This monograph addresses fundamental and applied scientific questions and is intended to assist scientists and practitioners bridge gaps in the current scientific knowledge in the areas of theoretical fluids dynamics, field measurements, and experiments for different practical applications. Readers of this book will include researchers, engineers, and professionals within academia, Federal agencies, and industry, as well as graduate/undergraduate students involved in theoretical, experimental, and numerical modeling studies of fluid dynamics and reactive chemical transport in the unsaturated and saturated zones, including studies pertaining to petroleum and geothermal reservoirs, environmental management and remediation, mining, gas storage, and radioactive waste isolation in underground repositories. Volume highlights include discussions of the following: Fundamentals of using a complex systems approach to describe flow and transport in fractured-porous media. Methods of Field Measurements and Experiments Collective behavior and emergent properties of complex fractured rock systems Connection to the surrounding environment Multi-disciplinary research for different applications

The book sets the standard on carbon materials for electrode design. For the first time, the leading experts in this field summarize the preparation techniques and specific characteristics together with established and potential applications of the different types of carbon-based electrodes. An introductory chapter on the properties of carbon together with chapters on the electrochemical characteristics and properties of the different modifications of carbon such as carbon nanotubes, graphene, carbon fiber, diamond or highly ordered pyrolytic graphite provide the reader with the basics on this fascinating and ubiquitous electrode material. Cutting-edge technologies such as carbon electrodes in efficient supercapacitors, Li-ion batteries and fuel cells, or electrodes prepared by screen-printing are discussed, giving a complete but concise overview about the topic. The clearly structured book helps newcomers to grasp easily the principles of carbon-based electrodes, while researchers in fundamental and applied electrochemistry will find new ideas for further research on related key technologies.

Volume XVII in the «Advances in Electrochemical Science and Engineering» series, this monograph covers progress in this rapidly developing field with a particular emphasis on important applications, including spectroscopy, medicinal chemistry and analytical chemistry. As such it covers nanopatterned and nanoparticle-modified electrodes for analytical detection, surface spectroscopy, electrocatalysis and a fundamental understanding of the relation between the electrode structure and its function. Written by a group of international experts, this is a valuable resource for researchers working in such fields as electrochemistry, materials science, spectroscopy, analytical and medicinal chemistry.

Catalysts speed up a chemical reaction or allow for reactions to take place that would not otherwise occur. The chemical nature of a catalyst and its structure are crucial for interactions with reaction intermediates. An electrocatalyst is used in an electrochemical reaction, for example in a fuel cell to produce electricity. In this case, reaction rates are also dependent on the electrode potential and the structure of the electrical double-layer. This work provides a valuable overview of this rapidly developing field by focusing on the aspects that drive the research of today and tomorrow. Key topics are discussed by leading experts, making this book a must-have for many scientists of the fi eld with backgrounds in different disciplines, including chemistry, physics, biochemistry, engineering as well as surface and materials science. This book is volume XIV in the series «Advances in Electrochemical Sciences and Engineering».

Sets the stage for advances in drug discovery using the latest enzyme technology Reviewing new and emerging applications of enzyme technology in drug discovery, this book highlights some of the most promising areas of pharmaceutical and biotechnology research. It covers enzyme assay technology, utilization of enzymology for prodrug design, and the application of enzymes as therapeutic agents. Expert reviews highlight how our latest understanding of enzymology is used to develop new practical applications in drug discovery and design. Filled with case studies, Enzyme Technologies: Pluripotent Players in Discovering Therapeutic Agents enables readers to better understand the diverse functions of enzymes and master specific applications in drug discovery research. In addition to small molecule drug discovery, the book explores new developments in enzymes as therapeutic agents for genetic disorders. Section A, Enzymes – Essential Workhorses in Pharmaceutical Research, offers support in selecting the best enzyme targets for drug discovery, designing enzyme inhibitors for therapeutic agents, and evaluating selective enzyme inhibitors. Section B, Enzymes – Indispensable Tools for Improving Druggability, sets forth the principles alongside real-world examples of exploiting specific properties of enzymes to design successful prodrugs. Section C, Enzymes – Powerful Weapons for Correcting Nature's Errors, provides new insights on applying enzymes as therapeutic agents or diagnostic tools to treat genetic disorders. Chapters are contributed by leading experts from around the world. Their contributions are based on a thorough review of the current literature as well as their own research. Reviewing our latest understanding of the nature of enzymes and their role in drug discovery, this book is recommended for researchers in pharmaceuticals and biotechnology as well as for researchers in enzymology, biochemistry, molecular biology, and medicinal chemistry.

Addressing the exploding interest in bioengineering for healthcare applications, this book provides readers with detailed yet easy-to-understand guidance on biomedical device engineering. Written by prominent physicians and engineers, Medical Devices: Surgical and Image-Guided Technologies is organized into stand-alone chapters covering devices and systems in diagnostic, surgical, and implant procedures. Assuming only basic background in math and science, the authors clearly explain the fundamentals for different systems along with such topics as engineering considerations, therapeutic techniques and applications, future trends, and more. After describing how to manage a design project for medical devices, the book examines the following: Instruments for laparoscopic and ophthalmic surgery, plus surgical robotics Catheters in vascular therapy and energy-based hemostatic surgical devices Tissue ablation systems and the varied uses of lasers in medicine Vascular and cardiovascular devices, plus circulatory support devices Ultrasound transducers, X-ray imaging, and neuronavigation An absolute must for biomedical engineers, Medical Devices: Surgical and Image-Guided Technologies is also an invaluable guide for students in all engineering majors and pre-med programs interested in exploring this fascinating field.

Cytogenetics is the study of chromosome morphology, structure, pathology, function, and behavior. The field has evolved to embrace molecular cytogenetic changes, now termed cytogenomics. Cytogeneticists utilize an assortment of procedures to investigate the full complement of chromosomes and/or a targeted region within a specific chromosome in metaphase or interphase. Tools include routine analysis of G-banded chromosomes, specialized stains that address specific chromosomal structures, and molecular probes, such as fluorescence in situ hybridization (FISH) and chromosome microarray analysis, which employ a variety of methods to highlight a region as small as a single, specific genetic sequence under investigation. The AGT Cytogenetics Laboratory Manual, Fourth Edition offers a comprehensive description of the diagnostic tests offered by the clinical laboratory and explains the science behind them. One of the most valuable assets is its rich compilation of laboratory-tested protocols currently being used in leading laboratories, along with practical advice for nearly every area of interest to cytogeneticists. In addition to covering essential topics that have been the backbone of cytogenetics for over 60 years, such as the basic components of a cell, use of a microscope, human tissue processing for cytogenetic analysis (prenatal, constitutional, and neoplastic), laboratory safety, and the mechanisms behind chromosome rearrangement and aneuploidy, this edition introduces new and expanded chapters by experts in the field. Some of these new topics include a unique collection of chromosome heteromorphisms; clinical examples of genomic imprinting; an example-driven overview of chromosomal microarray; mathematics specifically geared for the cytogeneticist; usage of ISCN’s cytogenetic language to describe chromosome changes; tips for laboratory management; examples of laboratory information systems; a collection of internet and library resources; and a special chapter on animal chromosomes for the research and zoo cytogeneticist. The range of topics is thus broad yet comprehensive, offering the student a resource that teaches the procedures performed in the cytogenetics laboratory environment, and the laboratory professional with a peer-reviewed reference that explores the basis of each of these procedures. This makes it a useful resource for researchers, clinicians, and lab professionals, as well as students in a university or medical school setting.

Why do earthquakes happen? What properties control the dynamic rupture and what are the processes at play? Chapters in the present volume capture the current state of the art by displaying an overview of the existing knowledge on the physics of dynamic faulting and promote multidisciplinary contributions on the observational and experimental fault fabric and mechanics, the evolution of fault zone physical and chemical properties, dynamic rupture processes and physically, and observationally, consistent numerical modeling of fault zone during seismic rupture. This volume examines questions such as: What are the dynamics processes recorded in fault gouge? What can we learn on rupture dynamic from laboratory experiments? How on-fault and off-fault properties affect seismic ruptures? How do they evolve trough time? Insights from physically, and observationally, consistent numerical modeling Fault Zone Dynamic Processes: Evolution of Fault Properties During Seismic Rupture is a valuable contribution for Earth’s scientists, researchers and students interested in the earthquakes processes and properties of on-fault and off-fault zones. Its multidisciplinary content is relevant to a broad audience: structural geologist, experimentalists, rocks mechanicians, seismologist, geophysicists and modelers.

Providing a concise, yet comprehensive, reference on all aspects of industrial exposures and toxicants; this book aids toxicologists, industrial hygienists, and occupational physicians to investigate workplace health problems. • Updates and expands coverage with new chapters covering regulatory toxicology, toxicity testing, physical hazards, high production volume (HPV) chemicals, and workplace drug use • Includes information on occupational and environmental sources of exposure, mammalian toxicology, industrial hygiene, medical management and ecotoxicology • Retains a succinct chapter format that has become the hallmark for the previous editions • Distils a vast amount of information into one resource for both academics and professionals

A valuable handbook containing reviews, practical methods and standard operating procedures. A valuable and practical working handbook containing introductory and specialist content that tackles a major and growing field of environmental, microbiological and ecotoxicological monitoring and analysis Includes introductory reviews, practical analytical chapters and a comprehensive listing of almost thirty Standard Operating Procedures (SOPs) For use in the laboratory, in academic and government institutions and industrial settings

Several scholars across the globe identified the present lack of high quality damage data as the main constraint to efficient risk mitigation. The need for a systematic collection of damage data in the aftermath of flood events come into light, thus the aim being the creation of complete and reliable databases. Flood damage data collected in the aftermath of a disastrous event can support a variety of actions, which include: (i) the identification of priorities for intervention during emergencies, (ii) the creation of complete event scenarios on the basis of which understanding the fragilities of the flooded areas and tailoring risk mitigation strategies, (iii) the definition of victims compensation schemes, and (iv) the validation/definition of damage models to feed cost-benefit analysis of structural and non-structural mitigation actions (including insurance schemes). Volume highlights include: A good compilation of real world case studies elaborating on the survey experiences and best practices associated with flood damage data collection, storage and analysis, that can help strategize flood risk mitigation in an efficient manner Valuable contributions covering different flooding phenomena such as riverine and mountain floods, different spatial level of analysis from local to global scales, and different stakeholders perspectives, e.g. public decision makers, researchers, private companies Contributions from leading experts in the field, researchers and practitioners, including civil protection actors working at different spatial and administrative level, insurers and professionals working in the field of natural hazards mitigation Flood Damage Survey and Assessment: New Insights from Research and Practice will be a valuable resource to all earth scientists, hydrologists, meteorologists, geologists, geographers, civil engineers, insurers and policy decision makers.

Brain–computer interfaces (BCI) are devices which measure brain activity and translate it into messages or commands, thereby opening up many investigation and application possibilities. This book provides keys for understanding and designing these multi-disciplinary interfaces, which require many fields of expertise such as neuroscience, statistics, informatics and psychology. This first volume, Methods and Perspectives, presents all the basic knowledge underlying the working principles of BCI. It opens with the anatomical and physiological organization of the brain, followed by the brain activity involved in BCI, and following with information extraction, which involves signal processing and machine learning methods. BCI usage is then described, from the angle of human learning and human-machine interfaces. The basic notions developed in this reference book are intended to be accessible to all readers interested in BCI, whatever their background. More advanced material is also offered, for readers who want to expand their knowledge in disciplinary fields underlying BCI. This first volume will be followed by a second volume, entitled Technology and Applications