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Fluoropolymers continue to enable new materials and technologies as a result of their remarkable properties. This book reviews fluoropolymer platforms of established commercial interest, as well as recently discovered methods for the preparation and processing of new fluorinated materials. It covers the research and development of fluoropolymer synthesis, characterization, and processing. Emphasis is placed on emerging technologies in optics, space exploration, fuel cells, microelectronics, gas separation membranes, biomedical instrumentation, and much more. In addition, the book covers the current environmental concerns associated with fluoropolymers, as well as relevant regulations and potential growth opportunities. Concepts, studies, and new discoveries are taken from leading international laboratories, including academia, government, and industrial institutions.

Covers a widespread view of Quality by Design (QbD) encompassing the many stages involved in the development of a new drug product. The book provides a broad view of Quality by Design (QbD) and shows how QbD concepts and analysis facilitate the development and manufacture of high quality products. QbD is seen as a framework for building process understanding, for implementing robust and effective manufacturing processes and provides the underpinnings for a science-based regulation of the pharmaceutical industry. Edited by the three renowned researchers in the field, Comprehensive Quality by Design for Pharmaceutical Product Development and Manufacture guides pharmaceutical engineers and scientists involved in product and process development, as well as teachers, on how to utilize QbD practices and applications effectively while complying with government regulations. The material is divided into three main sections: the first six chapters address the role of key technologies, including process modeling, process analytical technology, automated process control and statistical methodology in supporting QbD and establishing the associated design space. The second section consisting of seven chapters present a range of thoroughly developed case studies in which the tools and methodologies discussed in the first section are used to support specific drug substance and drug-product QbD related developments. The last section discussed the needs for integrated tools and reviews the status of information technology tools available for systematic data and knowledge management to support QbD and related activities. Highlights Demonstrates Quality by Design (QbD) concepts through concrete detailed industrial case studies involving of the use of best practices and assessment of regulatory implications Chapters are devoted to applications of QbD methodology in three main processing sectors—drug substance process development, oral drug product manufacture, parenteral product processing, and solid-liquid processing Reviews the spectrum of process model types and their relevance, the range of state-of-the-art real-time monitoring tools and chemometrics, and alternative automatic process control strategies and methods for both batch and continuous processes The role of the design space is demonstrated through specific examples and the importance of understanding the risk management aspects of design space definition is highlighted Comprehensive Quality by Design for Pharmaceutical Product Development and Manufacture is an ideal book for practitioners, researchers, and graduate students involved in the development, research, or studying of a new drug and its associated manufacturing process.

Over the past decade, renewables-based technology and sustainability assessment methods have grown tremendously. Renewable energy and products have a significant role in the market today, and the same time sustainability assessment methods have advanced, with a growing standardization of environmental sustainability metrics and consideration of social issues as part of the assessment. Sustainability Assessment of Renewables-Based Products: Methods and Case Studies is an extensive update and sequel to the 2006 title Renewables-Based Technology: Sustainability Assessment. It discusses the impressive evolution and role renewables have taken in our modern society, highlighting the importance of sustainability principles in the design phase of renewable-based technologies, and presenting a wide range of sustainability assessment methods suitable for renewables-based technologies, together with case studies to demonstrate their applications. This book is a valuable resource for academics, businesses and policy makers who are active in contributing to more sustainable production and consumption. For more information on the Wiley Series in Renewable Resources, visit www.wiley.com/go/rrs Topics covered include: The growing role of renewables in our society Sustainability in the design phase of products and processes Principles of sustainability assessment Land use analysis Water use analysis Material and energy flow analysis Exergy and cumulative exergy analysisCarbon and environmental footprint methods Life Cycle Assessment (LCA), social Life Cycle Assessment and Life Cycle Costing (LCC) Case studies: renewable energy, bio-based chemicals and bio-based materials.

Principles of Stem Cell Biology and Cancer: Future Applications and Therapeutics Tarik Regad, The John van Geest Cancer Research Centre, Nottingham Trent University, UK, Thomas J. Sayers, Centre for Cancer Research, National Cancer Institute, Frederick, USA and Robert Rees The John van Geest Cancer Research Centre, Nottingham Trent University, UK The field of cancer stem cells is expanding rapidly, with many groups focusing on isolating and identifying cancer stem cell populations. Although some progress has been made developing efficient cancer therapies, targeting cancer stem cells remains one of the important challenges facing the growing stem cell research community. Principles of Stem Cell Biology and Cancer brings together original contributions from international experts in the field to present the very latest information linking stem cell biology and cancer. Divided into two parts, the book begins with a detailed introduction to stem cell biology with a focus on the characterization of these cells, progress that has been made in their identification, as well as future therapeutic applications of stem cells. The second part focuses on cancer stem cells and their role in cancer development, progression and chemo-resistance. This section of the book includes an overview of recent progress concerning therapies targeting cancer stem cells. Features: An authoritative introduction to the link between stem cell biology and cancer. Includes contributions from leading international experts in the field. Well-illustrated with full colour figures throughout. This book will prove an invaluable resource for basic and applied researchers and clinicians working on the development of new cancer treatments and therapies, providing a timely publication of high quality reviews outlining the current progress and exciting future possibilities for stem cell research.

The workbook that helps students connect emotional intelligence with leadership skills The Emotionally Intelligent Leadership for Students: Student Workbook contains hands-on activities and case studies to help students foster the 19 capacities of emotionally intelligent leadership (EIL) presented in the main text Emotionally Intelligent Leadership: A Guide for Students. Research from around the world has demonstrated that there is a relationship between emotional intelligence and leadership. For the substantially revised second edition, the authors have completely rewritten all modules and activities according to their data-based model. These activities bring theory into practice, targeting specific learning outcomes that will help students become better leaders. The workbook can be used in conjunction with the Emotionally Intelligent Leadership for Students: Inventory which helps students to assess their leadership behaviors. The companion Emotionally Intelligent Leadership for Students: Facilitation and Activity Guide is aligned with the workbook to serve as a road map for educators. Contains 23 all new modules consisting of activities and case studies that further the understanding and relevancy of the emotionally intelligent leadership model Reflects 19 emotionally intelligent leadership capacities derived from new research research that provides evidence of construct validity Can be used as a self-guided experience for developing capacities of EIL Includes tips for improving each leadership capacity, suggestions for further reading, and films to watch The Emotionally Intelligent Leadership for Students suite of resources offers an immersive and transformative educational experience, fostering growth and promoting intense self-reflection. Students will be empowered to develop into the effective leaders of the future.

Provides a review of novel pharmaceutical approaches for Tuberculosis drugs Presents a novel perspective on tuberculosis prevention and treatment Considers the nature of disease, immunological responses, vaccine and drug delivery, disposition and response Multidisciplinary appeal, with contributions from microbiology, immunology, molecular biology, pharmaceutics, pharmacokinetics, chemical and mechanical engineering

This practical guide for advanced students and decision-makers in the pharma and biotech industry presents key success factors in R&D along with value creators in pharmaceutical innovation. A team of editors and authors with extensive experience in academia and industry and at some of the most prestigious business schools in Europe discusses in detail the innovation process in pharma as well as common and new research and innovation strategies. In doing so, they cover collaboration and partnerships, open innovation, biopharmaceuticals, translational medicine, good manufacturing practice, regulatory affairs, and portfolio management. Each chapter covers controversial aspects of recent developments in the pharmaceutical industry, with the aim of stimulating productive debates on the most effective and efficient innovation processes. A must-have for young professionals and MBA students preparing to enter R&D in pharma or biotech as well as for students on a combined BA/biomedical and natural sciences program.

The Wave Concept Iterative Procedure (WCIP) method has found an increasing number of users within electromagnetic theory and applications to planar circuits, antennas and diffraction problems. This book introduces in detail this new formulation of integral methods, based on the use of a wave concept with two bounded operators, and applications in a variety of domains in electromagnetics. This approach presents a number of benefits over other integral methods, including overcoming the problem of singularity, and reduced computing time. Through the presentation of mathematical equations to characterize studied structures and explanation of the curves obtained, via validated examples, the authors provide a thorough background to electromagnetism as well as a professional reference to students and researchers.

Forest trees and shrubs play vital ecological roles, reducing the carbon load from the atmosphere by using carbon dioxide in photosynthesis and by the storage of carbon in biomass and wood as a source of energy. Autoecology deals with all aspects of woody plants; the dynamism of populations, physiological traits of trees, light requirements, life history patterns, and physiological and morphological characters. Ecophysiology is defined by various plant growth parameters such as leaf traits, xylem water potential, plant height, basal diameter, and crown architecture which are, in turn, influenced by physiological traits and environmental conditions in the forest ecosystem. In short, this book details research advances in various aspects of woody plants to help forest scientists and foresters manage and protect forest trees and plan their future research. Autoecology and Ecophysiology of Woody Shrubs and Trees is intended to be a guide for students of woody plant autoecology and ecophysiology, as well as for researchers in this field. It is also an invaluable resource for foresters to assist in effective management of forest resources.

Medical technology is a fast growing field. This new title gives a comprehensive review of modern optical technologies alongside their clinical deployment. It bridges the technology and clinical domains and will be suitable in both technical and clinical environments. It introduces and develops basic physical methods (in optics, photonics, and metrology) and their applications in the design of optical systems for use in medical technology with a special focus on ophthalmology. Medical applications described in detail demonstrate the advantage of utilizing optical-photonic methods. Exercises and solutions for each chapter help understand and apply basic principles and methods. An associated website run by the authors will include slides to facilitate the teaching/training of this material, and typical images collected by the described methods, eg videos of endoscopy or navigation, OCT, etc.

Comprehensive and up-to-date, this book focuses on the latest advances in the field, such as newly developed techniques, more environmentally benign processes, broadened scopes, and completely novel MCRs. In addition to carbene-promoted MCRs and frequently applied metal-catalyzed MCRs, it also covers recently developed catalytic enantioselective variants as well as MCR in drug discovery and for the synthesis of heterocyclic molecules and macrocycles. Edited by the leading experts and with a list of authors reading like a «who's who» in multicomponent reaction chemistry, this is definitely a must-have for every synthetic organic chemist as well as medicinal chemists working in academia and pharmaceutical companies.

Uncertainties are pervasive in natural hazards, and it is crucial to develop robust and meaningful approaches to characterize and communicate uncertainties to inform modeling efforts. In this monograph we provide a broad, cross-disciplinary overview of issues relating to uncertainties faced in natural hazard and risk assessment. We introduce some basic tenets of uncertainty analysis, discuss issues related to communication and decision support, and offer numerous examples of analyses and modeling approaches that vary by context and scope. Contributors include scientists from across the full breath of the natural hazard scientific community, from those in real-time analysis of natural hazards to those in the research community from academia and government. Key themes and highlights include: Substantial breadth and depth of analysis in terms of the types of natural hazards addressed, the disciplinary perspectives represented, and the number of studies included Targeted, application-centered analyses with a focus on development and use of modeling techniques to address various sources of uncertainty Emphasis on the impacts of climate change on natural hazard processes and outcomes Recommendations for cross-disciplinary and science transfer across natural hazard sciences This volume will be an excellent resource for those interested in the current work on uncertainty classification/quantification and will document common and emergent research themes to allow all to learn from each other and build a more connected but still diverse and ever growing community of scientists.