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This classical textbook in the best sense of the word is now completely revised, updated and with more than 40 % new content. The approved ordering system according to the ring size of the heterocycles has been retained, while the important chapter on «Problems and their Solutions» has been almost completely renewed by introduction of up-to-date scientific exercises, resulting in a great tool for self-testing and exams. There was maintained a chapter on nomenclature and a helpful index of name reactions. With approximately 1,000 new literature citations, this book remains a brilliant gateway to modern heterocyclic science for master and graduate students, as well as PhDs and researchers entering the field. «If you want quick information about the basic (or acidic!) properties of a heterocycle, some interesting facts, or an assorted few ways of making it, this book provides a welcoming, accurate, and concise introduction.» Angewandte Chemie IE «Eicher, Speicher and Hauptmann provide an up to date introduction to the field for the advanced undergraduate and graduate students. … The book is carefully produced to a very high standard.» European Journal of Medicinal Chemistry

The book is a comprehensive treatment of the field, covering fundamental theoretical principles and new technological advancements, state-of-the-art device design, and reviewing examples encompassing a wide range of related sub-areas. In particular, the first area focuses on the recent development of novel wearable and implantable antenna concepts and designs including metamaterial-based wearable antennas, microwave circuit integrated wearable filtering antennas, and textile and/or fabric material enabled wearable antennas. The second set of topics covers advanced wireless propagation and the associated statistical models for on-body, in-body, and off-body modes. Other sub-areas such as efficient numerical human body modeling techniques, artificial phantom synthesis and fabrication, as well as low-power RF integrated circuits and related sensor technology are also discussed. These topics have been carefully selected for their transformational impact on the next generation of body-area network systems and beyond.

A blend of introductory material and advanced signal processing and communication techniques, of critical importance to underwater system and network development This book, which is the first to describe the processing techniques central to underwater OFDM, is arranged into four distinct sections: First, it describes the characteristics of underwater acoustic channels, and stresses the difference from wireless radio channels. Then it goes over the basics of OFDM and channel coding. The second part starts with an overview of the OFDM receiver, and develops various modules for the receiver design in systems with single or multiple transmitters. This is the main body of the book. Extensive experimental data sets are used to verify the receiver performance. In the third part, the authors discuss applications of the OFDM receiver in i) deep water channels, which may contain very long separated multipath clusters, ii) interference-rich environments, where an unintentional interference such as Sonar will be present, and iii) a network with multiple users where both non-cooperative and cooperative underwater communications are developed. Lastly, it describes the development of a positioning system with OFDM waveforms, and the progress on the OFDM modem development. Closely related industries include the development and manufacturing of autonomous underwater vehicles (AUVs) and scientific sensory equipment. AUVs and sensors in the future could integrate modems, based on the OFDM technology described in this book. Contents includes: Underwater acoustic channel characteristics/OFDM basics/Peak-to-average-ratio control/Detection and Doppler estimation (Doppler scale and CFO)/Channel estimation and noise estimation/A block-by-block progressive receiver and performance results/Extensions to multi-input multi-output OFDM/Receiver designs for multiple users/Cooperative underwater OFDM (Physical layer network coding and dynamic coded cooperation)/Localization with OFDM waveforms/Modem developments A valuable resource for Graduate and postgraduate students on electrical engineering or physics courses; electrical engineers, underwater acousticians, communications engineers

Neotectonics involves the study of the motions and deformations of the Earth's crust that are current or recent in geologic time. The Mediterranean region is one of the most important regions for neotectonics and related natural hazards. This volume focuses on the neotectonics of the Eastern Mediterranean region, which has experienced many major extensive earthquakes, including the devastating Izmit, Turkey earthquake on August 17, 1999. The event lasted for 37 seconds, killing around 17,000 people, injuring 44,000 people, and leaving approximately half a million people homeless. Since then, several North American, European, and Turkish research groups have studied the neotectonics and earthquake potential of the region using different geological and geophysical methods, including GPS studies, geodesy, and passive source seismology. Some results from their studies were presented in major North American and European geological meetings. This volume highlights the work involving the Eastern Mediterranean region, which has one of the world's longest and best studied active strike-slip (horizontal motion) faults: the east-west trending North Anatolian fault zone, which is very similar to the San Andreas fault in California. This volume features discussions of: Widespread applications in measuring plate motion that have strong implications in predicting natural disasters like earthquakes, both on a regional and a global scale Recent motions, particularly those produced by earthquakes, that provide insights on the physics of earthquake recurrence, the growth of mountains, orogenic movements, and seismic hazards Unique methodical approaches in collecting tectonophysical data, including field, seismic, experimental, computer-based, and theoretical approaches. Active Global Seismology is a valuable resource for geoscientists, particularly in the field of tectonophysics, geophysics, geodynamics, seismology, structural geology, environmental geology, and geoengineering.

Fluorescent Biomolecules and their Building Blocks focuses on the design of fluorescent probes for the four major families of macromolecular building blocks. Compiling the expertise of multiple authors, this book moves from introductory chapters to an exploration of the design, synthesis, and implementation of new fluorescent analogues of biomolecular building blocks, including examples of small-molecule fluorophores and sensors that are part of biomolecular assemblies.

Unlike other handbooks in this emerging field, this guide focuses on the challenges and critical parameters in running a metabolomics study, including such often-neglected issues as sample preparation, choice of separation and detection method, recording and evaluating data as well as method validation. By systematically covering the entire workflow, from sample preparation to data processing, the insight and advice offered here helps to clear the hurdles in setting up and running a successful analysis, resulting in high-quality data from every experiment. Based on more than a decade of practical experience in developing, optimizing and validating metabolomics approaches as a routine technology in the academic and industrial research laboratory, the lessons taught here are highly relevant for all systems-level approaches, whether in systems biology, biotechnology, toxicology or pharmaceutical sciences. From the Contents: * Sampling and Sample Preparation in Microbial Metabolomics * Tandem Mass Spectrometry Hyphenated with HPLC and UHPLC for Targeted Metabolomics * GC-MS, LC-MS, CE-MS and Ultrahigh Resolution MS (FTICR-MS) in Metabolomics * NMR-based metabolomics analysis * Potential of Microfluidics and Single Cell Analysis in Metabolomics * Data Processing in Metabolomics * Validation and Measurement Uncertainty in Metabolomic Studies * Metabolomics and its Role in the Study of Mammalian Systems and in Plant Sciences * Metabolomics in Biotechnology and Nutritional Metabolomics and more.

GIS and Geocomputation for Water Resource Science and Engineering not only provides a comprehensive introduction to the fundamentals of geographic information systems but also demonstrates how GIS and mathematical models can be integrated to develop spatial decision support systems to support water resources planning, management and engineering. The book uses a hands-on active learning approach to introduce fundamental concepts and numerous case-studies are provided to reinforce learning and demonstrate practical aspects. The benefits and challenges of using GIS in environmental and water resources fields are clearly tackled in this book, demonstrating how these technologies can be used to harness increasingly available digital data to develop spatially-oriented sustainable solutions. In addition to providing a strong grounding on fundamentals, the book also demonstrates how GIS can be combined with traditional physics-based and statistical models as well as information-theoretic tools like neural networks and fuzzy set theory.

Hydrodynamics of Time-Periodic Groundwater Flow introduces the emerging topic of periodic fluctuations in groundwater. While classical hydrology has often focused on steady flow conditions, many systems display periodic behavior due to tidal, seasonal, annual, and human influences. Describing and quantifying subsurface hydraulic responses to these influences may be challenging to those who are unfamiliar with periodically forced groundwater systems. The goal of this volume is to present a clear and accessible mathematical introduction to the basic and advanced theory of time-periodic groundwater flow, which is essential for developing a comprehensive knowledge of groundwater hydraulics and groundwater hydrology. Volume highlights include: Overview of time-periodic forcing of groundwater systems Definition of the Boundary Value Problem for harmonic systems in space and time Examples of 1-, 2-, and 3-dimensional flow in various media Attenuation, delay, and gradients, stationary points and flow stagnation Wave propagation and energy transport Hydrodynamics of Time-Periodic Groundwater Flow presents numerous examples and exercises to reinforce the essential elements of the theoretical development, and thus is eminently well suited for self-directed study by undergraduate and graduate students. This volume will be a valuable resource for professionals in Earth and environmental sciences who develop groundwater models., including in the fields of groundwater hydrology, soil physics, hydrogeology, geoscience, geophysics, and geochemistry. Time-periodic phenomena are also encountered in fields other than groundwater flow, such as electronics, heat transport, and chemical diffusion. Thus, students and professionals in the field of chemistry, electronic engineering, and physics will also find this book useful.

The autobiography of a Nobel Prize winner, this book tells us about George Olah's fascinating research into extremely strong superacids and how it yielded the common term «magic acids.» Olah guides us through his long and remarkable journey, from Budapest to Cleveland to Los Angeles, with a stopover in Stockholm. This updated autobiography of a Nobel Prize winner George A. Olah: Chronicles the distinguished career of a chemist whose work in a broad range of chemistry areas, and most notably that in methane chemistry, led to technologies that impact the processing and utility of alternative fuels Is based on Olah's work on extremely strong superacids and how they yielded the common term, «magic acids» Details events since the publication of the first edition in 2000 Inspires readers with details on Dr. Olah's successful recent research on methanol, intended to help provide a solution to «the oil problem»

This research book covers the major aspects relating to the use of novel delivery systems in enhancing both transdermal and intradermal drug delivery. It provides a review of transdermal and intradermal drug delivery, including the history of the field and the various methods employed to produce delivery systems from different materials such as device design, construction and evaluation, so as to provide a sound background to the use of novel systems in enhanced delivery applications. Furthermore, it presents in-depth analyses of recent developments in this exponentially growing field, with a focus on microneedle arrays, needle-free injections, nanoparticulate systems and peptide-carrier-type systems. It also covers conventional physical enhancement strategies, such as tape-stripping, sonophoresis, iontophoresis, electroporation and thermal/suction/laser ablation Discussions about the penetration of the stratum corneum by the various novel strategies highlight the importance of the application method. Comprehensive and critical reviews of transdermal and intradermal delivery research using such systems focus on the outcomes of in vivoanimal and human studies. The book includes laboratory, clinical and commercial case studies featuring safety and patient acceptability studies carried out to date, and depicts a growing area for use of these novel systems is in intradermal vaccine delivery. The final chapters review recent patents in this field and describe the work ongoing in industry.

The Terrestrial Water Cycle: Natural and Human-Induced Changes is a comprehensive volume that investigates the changes in the terrestrial water cycle and the natural and anthropogenic factors that cause these changes. This volume brings together recent progress and achievements in large-scale hydrological observations and numerical simulations, specifically in areas such as in situ measurement network, satellite remote sensing and hydrological modeling. Our goal is to extend and deepen our understanding of the changes in the terrestrial water cycle and to shed light on the mechanisms of the changes and their consequences in water resources and human well-being in the context of global change. Volume highlights include: Overview of the changes in the terrestrial water cycle Human alterations of the terrestrial water cycle Recent advances in hydrological measurement and observation Integrated modeling of the terrestrial water cycle The Terrestrial Water Cycle: Natural and Human-Induced Changes will be a valuable resource for students and professionals in the fields of hydrology, water resources, climate change, ecology, geophysics, and geographic sciences. The book will also be attractive to those who have general interests in the terrestrial water cycle, including how and why the cycle changes.

Discover an enhanced synthetic approach to developing and screening chemical compound libraries Diversity-oriented synthesis is a new paradigm for developing large collections of structurally diverse small molecules as probes to investigate biological pathways. This book presents the most effective methods in diversity-oriented synthesis for creating small molecule collections. It offers tested and proven strategies for developing diversity-oriented synthetic libraries and screening methods for identifying ligands. Lastly, it explores some promising new applications based on diversity-oriented synthesis that have the potential to dramatically advance studies in drug discovery and chemical biology. Diversity-Oriented Synthesis begins with an introductory chapter that explores the basics, including a discussion of the relationship between diversity-oriented synthesis and classic combinatorial chemistry. Divided into four parts, the book: Offers key chemical methods for the generation of small molecules using diversity-oriented principles, including peptidomimetics and macrocycles Expands on the concept of diversity-oriented synthesis by describing chemical libraries Provides modern approaches to screening diversity-oriented synthetic libraries, including high-throughput and high-content screening, small molecule microarrays, and smart screening assays Presents the applications of diversity-oriented synthetic libraries and small molecules in drug discovery and chemical biology, reporting the results of key studies and forecasting the role of diversity-oriented synthesis in future biomedical research This book has been written and edited by leading international experts in organic synthesis and its applications. Their contributions are based on a thorough review of the current literature as well as their own firsthand experience developing synthetic methods and applications. Clearly written and extensively referenced, Diversity-Oriented Synthesis introduces novices to this highly promising field of research and serves as a springboard for experts to advance their own research studies and develop new applications.